Hence, based on these six genes, the HNSCC risk score system was established as follows: risk score= (0.6624 × expression value of ASNS) + (1.2499× expression value of EXOSC6) + (0.9704 × expression value of BAK1) + (1.1852 × expression value of TPP1) + (0.7885 × expression value of EXOSC8) + (-2.0666 × expression value of TATDN2). The gene discussed is TATDN2; the disease is head and neck squamous cell carcinoma.