CTLA4 and acute kidney injury: None of any ICI category (anti-PD-1, anti-PD-L1, or anti-CTLA-4) was more likely to cause AKI than the others (Supplementary Fig. 3), but the combination of anti-PD-1/ PD-L1 with anti-CTLA-4 (OR = 1.93, 95%CI 1.25–2.97) was found to be significantly correlated with AKI (Fig. 5).