Our present work revealed that SARS-CoV-2 infected the alveolar target cells AT1/AT2 to result in immune activation and release a large number of inflammation-related ligands and receptors (such as ANXA1_FPRs, CXCLs_CXCRs, CD74_APP, CD74_COPA, CCL5_CCRs) (Figs. 3 and 6H), which could further bind to their receptors on free myeloid cells in the lung cavity to rapidly induce their enrichment to the infection site. The gene discussed is COPA; the disease is infection.