APP and COVID-19: Of note, previous studies have indicated that the CXCLs_CXCRs family as known chemokines can induce the recruitment of Neu and Mono [15], and the ANXA1_FPR1 is related to the increase of myeloid cells of COVID-19 patients [16], as well as both CD74_COPA and CD74_APP can serve as inflammatory recruitment signals, particularly COPA is also reported to be involved in the occurrence of autoimmune interstitial lung and lipopneumonia [17, 18].