MYC and rectum adenocarcinoma: We first carried out The Cancer Genome Atlas analysis and found that in colon adenocarcinoma and rectal adenocarcinoma samples, both YTHDF1 and c-Myc are overexpressed in the tumor samples (Fig. 6, A and B), indicative of a positive correlation between YTHDF1 and c-Myc in colorectal cancer.