PHGDH and cancer: For example, ZFP36 bound to mRNAs encoding key enzymes involved in fatty acid biosynthesis (Fasn), serine synthesis (Phgdh), glutaminolysis (Gls), sphingolipid biosynthesis (Sptlc2), and glycolysis (Hk2, Pfkm, Pkm).27–32 Moreover, Slc2a1, the primary glucose transporter in proliferating and cancer cells, was also found bound by ZFP36 (Figure 2G).