Using Pcsk9 treatment in the absence of PCL, a recent report demonstrated increased lesion size in the brachiocephalic artery, but not aortic root, of 18–19 month compared to 2–3 month old C57Bl/6 mice treated with AAV-Pcsk9 and fed an AD for 10 weeks [26]. The gene discussed is PCSK9; the disease is Alzheimer disease.