In another study, CANA decreased the levels of TNFα, IL-1α, IL-6 and reactive oxygen species (ROS) in LPS-stimulated RAW264.7 macrophages, as well as TNFα and IL-1β in LPS-treated human leukemia monocytic cells (THP-1) (Xu et al. 2018). This evidence concerns the gene TNF and leukemia.