On day 10 pi, tumors in the vehicle control animals reached an MTV of 750 mm3, while significant tumor growth inhibition (TGI) was observed in 177Lu-FAP-2287, anti-PD-1 and the combination group with MTV of 266, 373 and 145 mm3, corresponding to a TGI of 74, 57, and 92%, respectively (P < 0.05, Fig. 2A, C). The gene discussed is FAP; the disease is neoplasm.