In P301S (at advanced stages) and rTg4510 tauopathy mice there is reduced delta and theta EEG power associating with sleep alterations [94, 95], and in an FTD-tauopathy mouse model EEG alpha power during the wake-state is decreased [96] indicative of an overall EEG slowing related to tau. The gene discussed is MAPT; the disease is frontotemporal dementia.