MAPT and proteostasis deficiencies: Elevated tau has been observed in young individuals with OSA [77], and brain-derived exosomes contain higher levels of total tau, pT181, and Aβ in those with OSA and MCI, compared to OSA alone (age range: 35–65) [78], indicating potentiation of NDD exosome-mediated spread of proteinopathy with sleep disturbances [79–84].