For behavioral variant FTD, there is evidence for a potential relationship of orexin dysregulation and the sleep disturbances in these patients (reviewed in [123]), yet similar to ALS, further work is needed to delineate the roles of TDP-43, tau and FUS pathology, and their homeostasis (see Table 1), on hypothalamic function and sleep. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.