HOOK1 and breast cancer: The aberrant expression of HOOK1 has been demonstrated in multiple malignancies, including ovarian cancer, breast cancer, lung cancer, and hepatocellular carcinoma.[4, 5, 6, 7] Moreover, more than 70 missense mutations involving HOOK1 have been identified in solid tumors.[8] However, the biological role and molecular mechanism of HOOK1 during RCC metastasis remains unexplored.