Interesting, levels of HOOK1 showed a negatively correlation with tumor PD‐L1, not PD‐1 expression in both cohorts (Figure 9B; Figure S8C, Supporting Information), which were further demonstrated in meletin treated PDX tumors and murine RCC cell Renca induced tumors (Figure 9C; Figure S8D, Supporting Information). Here, CD274 is linked to renal cell carcinoma.