Besides, the MEK/ERK (MAPK) signaling is a fundamental pathway in cellular carcinogenesis, and c‐Myc is a transcription factor that induces multiple oncogenes and cell cycle regulators to promote the survival and proliferation of tumor cells, which means the MAPK and c‐Myc pathway are also crucial in regulating RCC cell malignant phenotype. This evidence concerns the gene MYC and renal cell carcinoma.