Further, we found that VHL inhibition led to significantly decreased HOOK1 mRNA and protein expression in Caki‐1 cell line, while ectopic VHL augmented the expression of HOOK1 in VHL‐mutant RCC 786‐O and A498 cell line (Figure 3B,D; Figure S2F,G, Supporting Information). This evidence concerns the gene HOOK1 and renal cell carcinoma.