It was also reported that the protein levels of GSDME were significantly increased in the colonic mucosa of IBD patients compared to healthy controls and that GSDME increases the release of HMGB1 (one of the DAMPs that has been recognized) from intestinal epithelial cells (IECs), which contributes to CAC tumorigenesis [23]. The gene discussed is HMGB1; the disease is inflammatory bowel disease.