INS and Insulin resistance: On the contrary, upon PP1α downregulation while the expression of BACE remained unaffected both under insulin sensitive and insulin resistant conditions (Fig. 8D), PP1γ downregulation caused 130 ± 0.07% increase in expression of BACE under insulin sensitive condition (Fig. 8E, Lane 4 vs. Lane 2, ***p < 0.001) and 86 ± 0.04% increase under insulin resistance when compared to control (Fig. 8E, Lane 8 vs. Lane 6, δδδp < 0.001).