PPARGC1A and myocardial infarction: This study identified a new molecular regulatory mechanism of MI/RI, namely, miR-494-3p can inhibit the mitochondrial autophagy transition of cardiomyocytes by regulating PGC1-α, thus alleviating the occurrence of myocardial ischemia‒reperfusion injury and providing a new perspective for the prevention and treatment of MI/RI.