CD8A and neoplasm: Nevertheless, since Treg and M2 cells can directly inhibit the function of CD8+ T cells, and Treg cells can selectively sustain M2-like macrophage metabolic fitness [20], the high expression of CD36 and the high infiltration of Treg and M2 cells establish a vicious circle of immunosuppression, which together impair the function of CD8+ T cells, promoting tumor immune escape and poor prognosis of NSCLC patients.