To determine whether AMSC-Exo-342 could be implicated in sepsis-associated AKI by acting on cell autophagy, HK-2 cells were exposed to 10 nM autophagy activator Rapa or autophagy inhibitor 3-MA before LPS induction and treatment with AMSC-Exo-67 or AMSC-Exo-342. Here, TRERF1 is linked to acute kidney injury.