FLT3 and acute myeloid leukemia: Interestingly, the co-occurrence of FLT3-ITD, especially at high VAF (≥20%), was associated with a specific AML presentation with higher WBC counts, massive BM blast infiltrations with disappearance of more mature cells and a dominance of the AML-M1/M2 morphological subtypes (Fig. 2E–J, Supplementary Fig. 3, Supplementary Table 8) [23].