Several biomarkers from the list of our biomarker leads, namely, TNFRSF4, MATN3, and \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\upbeta $$\end{document}β-NGF-1 were also downregulated in the pre-dementia disease stage. This evidence concerns the gene MATN3 and dementia.