Eleven of the top 20 CSF biomarker leads associated with the rate of cognitive decline in patients diagnosed with dementia are involved in signalling pathways (TNFRSF4, TGF \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\upbeta $$\end{document}β-1, CLEC1B, GFRA2, TNFRSF6B, EPHB6, PLXNB1), cell migration (EPHB6), and cell adhesion (PVRL4, EPHB6). This evidence concerns the gene NECTIN4 and dementia.