To test this hypothesis, we performed CRISPR-Cas9 mediated ITGA6 knock-out in PFA cells using two different single guide RNA (sgRNA) sequences targeting ITGA6. As a result, we observed that PFA cells (Fig. 3h), but neither ZFTA cells (Fig. 3i) nor GBM cells (Supplementary Fig. 4i), showed a decrease in cell growth over time. The gene discussed is ITGA6; the disease is glioblastoma.