While transcriptional activation of LAMC1 by SV-induced neo-TADs may be a rare event and has not yet been functionally validated, we tested whether LAMC1 is essential for cell growth of PFA ependymoma tumors and performed genetic inhibition experiments against LAMC1 in the PFA cell line EPD210FH that harbors the chr1-chr8 translocation. Here, LAMC1 is linked to ependymoma.