The TREM2 AD-risk variants associated with reduced cellular activation (p.R47H, p.R62H, and p.H157Y)20,45 were associated with Mic.2 (Mic-reduced; Fig. 4a; generalized linear regression β = 0.23, p = 3.29 × 10−2; Supplementary Datasets 6c, 9). The gene discussed is TREM2; the disease is Alzheimer disease.