This is concordant with our predictions using transcriptional data (Fig. 6a and Supplementary Dataset 8), which showed that BIN1 is underexpressed in Mic-activated compared to both Mic-resting and Mic-proinflammatory (MS4A associated), suggesting that the role of BIN1 in AD risk is dependent on microglia activation. Here, BIN1 is linked to Alzheimer disease.