MAPT and Alzheimer disease: We identified SOX8, SREBF1, and NKX6-2 linked to myelination17,52,53, NFE2L2/NRF2 associated with multiple AD pathologies including Aβ, Tau, and oxidative stress54, and ZNF518A associated with increased somatic-mutational burden in AD oligodendrocytes55 (Fig. 4g and Supplementary Dataset 19).