HNRNPU and Alzheimer disease: Pathway analysis of the Oligo-spliceosome upregulated genes was enriched in genes related to ‘mRNA splicing, via spliceosome’ (Benjamini–Hochberg p = 1.42 × 10−41, Fig. 3g) mainly from the family of heterogeneous nuclear ribonucleoproteins (HNRNP), including HNRNPA1, HNRNPA2B1, HNRNPA3, HNRNPC, HNRNPD, HNRNPH3, HNRNPK, HNRNPM, and HNRNPU, which have previously been linked to late-onset AD (Supplementary Fig. 7h and Supplementary Dataset 17h)42.