Interestingly, Mic-stress showed a significant increase in the expression of MECP2 (linear mixed effects regression β = 0.67, Benjamini–Hochberg p = 3.20 × 10−10, Supplementary Fig. 7g), which has previously shown differential expression in AD brains and, when knocked down in microglia, caused NMDA receptor-dependent excitotoxic neuronal cell death in a mouse model of Rett syndrome41. The gene discussed is MECP2; the disease is Alzheimer disease.