We performed snRNA-seq on nuclei from the understudied parietal cortex from a cohort enriched in carriers of AD genetic variants in APP, PSEN1, TREM2, APOE, and the MS4A cluster (rs1582763-A, an intergenic resilience variant in the MS4A locus associated with increased levels of soluble TREM2 in CSF and reduced AD risk14). This evidence concerns the gene PSEN1 and Alzheimer disease.