The schematic summary showing the modulation of DDR and DSB repair mechanisms in GBM cells with different p53 status (wild-type versus mutated) in the presence or absence of an active Rho pathway confirms that attenuation of Rho pathway activity decreases DDR signaling and, thereafter, DSB repair in wild-type p53 cells (Fig. S4B). Here, RHO is linked to glioblastoma.