TP53 and glioblastoma: Considering that the TP53 gene is the main gene responsible for the phenotypic differences between GBM and LGG tissues versus normal tissues (Fig. 1B), we mined this gene set in a cell line database (CCLE), comparing one p53-wild-type GBM cell line (U87-MG) with three p53-mutated GBM cell lines (T98G, U138-MG, U251-MG) and found that these five Rho pathway genes are expressed at similar levels in p53-proficient and p53-deficient GBM cells (Fig. 1C).