While EEG seizure activity (epilepsy-like spikes; Fig. 6e) was induced in all animals, THC injection increased the latency to tonic-seizure onset (Fig. 6f) and decreased interictal-spike frequency (Fig. 6g) selectively in Glu-Gap43−/− mice compared to vehicle-treated littermates. This evidence concerns the gene GAP43 and epilepsy.