The authors supposed that JAG1-expressing breast cancer cells might be selected based on their survival of early adaptive immune surveillance, and then, these cells may colonize the bone by interacting with bone host cells.107,108 However, another reasonable explanation is that JAG1-expressing tumor cells might be selected and obtain a proliferation advantage in the bone microenvironment and then escape immune surveillance, leading not only to bone colonization but also to secondary dissemination. This evidence concerns the gene JAG1 and neoplasm.