Meng J and colleagues determined tumor-derived JAG1-mediated cancer cell immune evasion progression.137 JAG1-overexpressing breast cancer cells increase the expression and secretion of multiple cytokines, including IL6 and WNT1-inducible signaling pathway protein 1 (WISP1), to help recruit macrophages into the tumor microenvironment. This evidence concerns the gene CCN4 and cancer.