STING1 and neoplasm: Svoronos et al. demonstrated that estrogen receptor α expressed by human and murine bone marrow myeloid precursors activates the signal transducer and activation of transcription (STAT) 3 pathway via Janus kinase (JAK) 2 and Src nonreceptor tyrosine kinase.16 Activation of the cannabinoid receptors CB1 and CB2 expressed on immune cells mobilized functional MDSCs, contributing to the immunomodulatory effects of cannabinoids.17 Stimulator of interferon genes (STING) and the type I interferon pathway induce M-MDSC accumulation in tumor tissue via C-C chemokine receptor (CCR) 2.18