These findings may seem to contradict the data in Fig. 1g showing that PTHrP treatment increased the immunosuppressive activity of M-MDSCs in tumor-naïve mice, but we reasoned that the effects of PTHrP on the immunosuppressive activity of MDSCs may not be prominent in tumor-bearing mice because PTHrP may not be the only tumor-derived factor for MDSC function, and cytokines and growth factors released by tumor cells may increase and mask the effects of PTHrP. The gene discussed is PTHLH; the disease is neoplasm.