GPT and obesity due to melanocortin 4 receptor deficiency: Evidence from experimental studies was summarized in a meta-analysis of 12 RCTs involving 601 adults with overweight or obesity showing that replacing SSB with LNCB reduced body weight, body fat, BMI, intrahepatocellular lipid, but not other clinical parameters including liver enzymes i.e. alanine transaminase and aspartate aminotransferase [41].