The transcriptional profile of neutrophils at the end of NMP resembled a phenotype that we recently identified and characterized as aged/chronically activated/exhausted neutrophils in non-small cell lung cancer tumor tissues (Fig. 5A: reduced expression of CXCR1, CXCR2, PTGS2, SELL, and elevated expression of CXCR4, CD83, CCRL2, CCL3, CCL4, ICAM1)26. This evidence concerns the gene CXCR4 and non-small cell lung carcinoma.