GLIS3 and Alzheimer disease: The nearest gene to rs71567499 is PPARD, believed to be a potential risk factor of AD through its function and influence over plasma levels of lipids and apolipoproteins and its association with diabetes.29,30 On chromosome 9, rs10974405 is found near the protein-coding gene GLIS3, known to contain loci associated with both CSF tau and p-tau levels.31