Among them, located on chromosome 8 similar to our findings, genetic variation at the MTMR7/CNOT7/ZDHHC2/VPS37A locus (rs12056505) was shown to be associated with cognitive resilience among those with elevated levels of Aβ.32 The protective association was not explained by differences in tau deposition or cerebrovascular disease, but possibly linked to synaptic plasticity and hippocampal-dependent learning and memory. The gene discussed is ZDHHC2; the disease is cerebrovascular disorder.