SOCS2 and malignant colon neoplasm: Furthermore, in the study of colon cancer, Xu et al suggested that methyltransferase-like 3 regulated the levels of SOCS2 through modulating methylation-mediated SOCS2 RNA degradation, thereby disrupting the proliferative ability of tumor cells (Xu et al, 2020), indicating that the changes of SOCS2 expression may be related to the methylation modification.