In addition, we discovered that, when compared with other miRNAs with a low expression in PC and predicted to target with DNMT3A, only the overexpression of miR-532-3p in PC cells had the most significant inhibition on DNMT3A (Fig S3A and B), so we focused our study on miR-532-3p. This evidence concerns the gene DNMT3A and pachyonychia congenita.