SOCS2 and colonic neoplasm: Previous study also suggested that the overexpression of SOCS2 could suppress STAT5 activities (Yang et al, 2012); however, SOCS2 was epigenetically silenced through the hypermethylation of its promoter region, which was consistent with the previous finding that 5-AZA treatment up-regulated the SOCS2 expression in colon cancer cells (Letellier et al, 2014).