Furthermore, in the study of colon cancer, Xu et al suggested that methyltransferase-like 3 regulated the levels of SOCS2 through modulating methylation-mediated SOCS2 RNA degradation, thereby disrupting the proliferative ability of tumor cells (Xu et al, 2020), indicating that the changes of SOCS2 expression may be related to the methylation modification. The gene discussed is SOCS2; the disease is colonic neoplasm.