DSG2 and cancer: In line with this, our transcriptomic analyses revealed differential expression of multiple cell adhesion molecules in T1CAFs that have been associated with cancer cell invasion, such as DSG2,44, 45, 46CDH2,47, 48, 49CDH10,50PCDH9,51,52 and ITGB2. 53,54 Another way T1CAFs can facilitate cancer cell invasion is by actively remodeling the matrix into which the cancer cells invade.