Given that many recent studies have highlighted a considerable heterogeneity in CAF subsets and phenotypes that can be found within CRCs,6,7,10,29,42,43 it remains to be elucidated whether all T1CAFs or only a subpopulation of T1CAFs show differential expression of Wnt2 and other tumor-progression–related targets. The gene discussed is WNT2; the disease is neoplasm.