Whole-transcriptome analysis revealed differential expression of several targets in T1CAFs, which have been related to tumor progression, such as SCUBE3,33, 34, 35SEMA3C,36, 37, 38 and WNT2. 39The latter in particular has been studied extensively in the context of CAFs and CRC. This evidence concerns the gene WNT2 and colorectal carcinoma.