ESR1 and breast cancer: For molecular subtypes, the highest over the lowest compliance to a healthy lifestyle index likely reduces overall HR/OR of BC molecular subtypes: ER+/PR+(HR = 0.68; 95% CI: 0.63, 0.73), ER+/PR- (HR = 0.78; 95% CI: 0.67, 0.90), and ER-/PR- (HR = 0.77; 95% CI: 0.64, 0.92) (Figure 5); all present moderate certainty of evidence.