PPARGC1A and neoplasm: Furthermore, we assessed whether FAO induction downstream of p53 and fish oil depends on the identified PPARGC1a/PPARα axis. The NPP construct was modified to incorporate the Ppargc1a gene (Figure S4B), resulting in its overexpression in the tumor cells (Figures S4C and S4E) and, importantly, upregulation of p53-regulated FAO genes (Figure S4D).