CRB1 and Retinal dystrophy: Retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA) are inherited retinal dystrophies caused by mutations in, among others, the Crumbs homolog 1 (CRB1) gene (Den Hollander et al., 1999; Nguyen et al., 2022; Talib et al., 2017).