There are several mouse models described with mutations in the Crb1 and/or Crb2 gene mimicking the RP or LCA phenotype (Alves et al., 2013, Alves et al., 2014, Alves et al., 2019; Mehalow et al., 2003; van de Pavert et al., 2004, 2007a; Pellissier et al., 2013; Quinn et al., 2018, 2019a). Here, CRB1 is linked to Leber congenital amaurosis.