,55,56 Thus, increased FA oxidation without sufficient compensatory ROS scavenging makes hepatocytes vulnerable to oxidative stress, NAFLD and NASH, and further studies should explore whether targeted lowering of HIBCH activity in hepatocytes might be an effective therapeutic strategy to strengthen the capacity for both FA β-oxidation and ROS scavenging. This evidence concerns the gene HIBCH and metabolic dysfunction-associated steatotic liver disease.