PAM and Insulin resistance: Specifically, upregulated FOXP1 target genes were associated with heart development (ADRA1A, AKAP13, SLC8A1), insulin resistance (GYS1, PPP1R3A, TBC1D4) (Xirouchaki et al., 2016), and response to hypoxia (DNMT3A, PAM, SLC8A1); downregulated FOXP1 target genes were related to cell–cell junction organization (JUP, TJP1), regulation of ion transport (FGF13, KCNJ3, CACNA2D3) and regulation of membrane potential (ATP2A2, KCNJ3, CD36) (Fig. 4L).