ADRA1A and cardiomyopathy: Upregulated DEGs were associated with pro-fibrotic signaling, such as TGF-β signaling-associated genes (TGFB1, LTBP1, ANKRD1) and other cardiomyopathy-related signaling, such as the MAPK cascade (ADRA1A, EGR1, IL6R) (Figs. 3B and S2C; Table S2).