BRCA2 and breast cancer: Similar trends were observed for unaffected women, where BRCA1 (OR 2.34, 95% CI 2.13, 2.56) and BRCA2 (OR 1.25, 95% CI 1.16, 1.35), were associated with a significant increase in risk among women with a relative diagnosed ≤ 45 versus > 45 years of age with breast cancer (Table 5).