To better evaluate endocrine disturbances in dogs with pituitary apoplexy, investigation of hypothalamic‐pituitary‐adrenal axis function (eg, testing cortisol levels, adrenocorticotropic hormone stimulation, or dexamethasone suppression testing), thyroid function (eg, testing total T4 and thyroid‐stimulating hormone), and assessment of urinary concentration ability (eg, urinalysis, water deprivation testing, response to desmopressin acetate) should be considered. Here, POMC is linked to pituitary apoplexy.