In contrast, the m.8950G>A variant was found in two unrelated patients: alone in a female with LHON plus dystonia (Abu-Amero and Bosley, 2005) and in combination with the m.13513G>A leading to p.D393N substitution in the ND5 subunit of the respiratory chain complex I in an individual with Leigh-like syndrome (Brautbar et al., 2008). This evidence concerns the gene MT-ND5 and Dystonia.