It can cause endothelial cell damage, increase the expression of adhesion molecules and other inflammatory mediators, and play an important role in the development of Cardiovascular and cerebrovascular diseases.[33] Bax, a Bcl-2 homologue, inhibits the action of Bcl-2 and promotes apoptosis, while Bcl-2 inhibits apoptosis. Here, BAX is linked to cerebrovascular disorder.