CD4 and stroke disorder: Regarding that neutrophil-derived serine proteases and nucleosomes from NETs may induce large vessel thrombosis leading to AMI and stroke, which significantly promotes thrombosis of NETs in both humans and animals.[43] Th17 cells, a newly discovered CD4 + T lymphocyte subpopulation in recent years, can secrete not only IFN-γ but also IL-17, which is the main effector of Th17 cell subpopulation.