Overlapping genes between the target genes of active compounds and liver fibrosis-related genes, including PTGS2, GABRA1, PTGS1, HSP90AB1, PGR, CHRM1, PRSS1, CHRM2, CASP3, and DPP4, may play an important role in the treatment of liver fibrosis. Here, PRSS1 is linked to Hepatic fibrosis.