PI3K-Akt signaling pathway is involved in inflammation.[7] Furthermore, inflammation is also involved in diseases that may cause liver fibrosis, such as hepatosteatosis, and viral and autoimmune hepatitis.[8–10] Thus, studying the effects of peach kernel and safflower herb-pair (PKSH) on inhibiting inflammatory response through the PI3K-AKT pathway for the treatment of liver fibrosis makes sense. The gene discussed is AKT1; the disease is autoimmune hepatitis.