ESR1 and Hepatic fibrosis: By analyzing the diagram, targets including EGFR, AKT1, MYC, RELA, JUN, MAPK1, FOS, HIF1A, CTNNB1, CCND1, ESR1, TP53, RUNX2, RB1, and CDKN1A may be core targets of the PKSH in the treatment of liver fibrosis (Fig. 3).