Platelet count is commonly elevated in active inflammatory bowel disease,[33,34] the mechanisms of which are thought to be mediated by several proinflammatory cytokines, including IL-6 and TNF-α.[18,35] In concert, alleviation of inflammatory processes contributes to the improvement in blood abnormalities, which varies in time course and efficacy depending on the treatment modalities used. The gene discussed is TNF; the disease is inflammatory bowel disease.