The characteristic pathological findings of GCA included goblet cell morphology with rich intracytoplasmic mucin and a small compressed nucleus, and concentric infiltration of the appendiceal wall by small tight clusters, cords, or nests of tumor cells.[25] The 3 tier grading systems of GCA was based on the proportion of goblet-like mucinous cells. This evidence concerns the gene MUC5AC and neoplasm.