As shown in the heatmap (Figure 2B), ‘writers’ (WTAP), ‘Readers’ (YTHDF1, YTHDF2, YTHDF3, HNRNPC, IGFBP1, IGFBP2, IGFBP3, RBMX, and ALKBH5) and ‘erasers’ (ALKB5H) in GBM samples were distinctly higher than those in LGG samples. The gene discussed is IGFBP3; the disease is glioblastoma.