As shown in the heatmap (Figure 2B), ‘writers’ (WTAP), ‘Readers’ (YTHDF1, YTHDF2, YTHDF3, HNRNPC, IGFBP1, IGFBP2, IGFBP3, RBMX, and ALKBH5) and ‘erasers’ (ALKB5H) in GBM samples were distinctly higher than those in LGG samples. This evidence concerns the gene IGFBP1 and glioblastoma.