RYR1 and Qualitative or quantitative defects of caveolin-3: In agreement, it was shown that myotubes from caveolinopathy patients present a reduction in both depolarization-induced Ca2+ release and influx (Ullrich et al., 2011) with disarrays in the colocalization of the DHPR and RyR1, thereby reducing the efficiency of excitation-contraction coupling.