While caveolinopathy patients form overall normal triads, their muscles present aggregation of Cav3 at the Golgi apparatus leading to a drastic decrease in the amount of Cav3 at the plasma membrane as well as defects in T-tubule morphology which may explain in part the occurrence of myalgias and exercise intolerance characteristic of these patients (Gazzerro et al., 2010; Minetti et al., 2002; Brauers et al., 2010; Sotgia et al., 2003). This evidence concerns the gene CAV3 and caveolinopathy.