The importance of these proteins in skeletal muscle physiology is emphasized by the fact that mutations in the CAV3 gene cause autosomal dominant neuromuscular diseases called caveolinopathies (Aboumousa et al., 2008; Gazzerro et al., 2010; Woodman et al., 2004) and mutations in BIN1 induce T-tubule and triad defects in the autosomal recessive form of centronuclear myopathy (Nicot et al., 2007). Here, CAV3 is linked to caveolinopathy.