In a large Danish cohort, compared with patients who had never used statins, statin users presented with significantly reduced cancer-related deaths for 13 different cancer types, including breast cancer.6 Likewise, a retrospective study found that statin use was associated with risk reduction in all subtypes of breast cancer, especially in patients with estrogen receptor–positive and EBBR2-negative invasive breast cancer.7 This finding implies a plausible link between statin use and outcomes in female patients with cancer. The gene discussed is ESR1; the disease is cancer.