On sensitivity analysis with the addition of hypertension, insulin-dependent diabetes, non–insulin-dependent diabetes, and body mass index (BMI) to the covariates above, LOY retained the positive association with SHBG (β = 0.08; 95% CI, 0.07 to 0.10; P = 4.61 × 10−21) and TT (β = 0.05; 95% CI, 0.04 to 0.07; P = 4.13 × 10−9; Fig. 1B and table S2). The gene discussed is SHBG; the disease is Hypertension.