For example, the histidine-rich protein 2 (hrp2) gene (PF3D7_0831800), which is widely used as a target for malaria rapid diagnostic tests (RDTs), already possessed a large deletion in Mut P0 and was completely replaced by the telomeric sequence in Mut4 during long-term passage (Fig. S7A–C). This evidence concerns the gene MMUT and malaria.