Fibroblasts from other HSE patients with AR complete deficiencies of the TLR3 pathway (TLR3, TRIF, or UNC93B1) (19, 21, 28), serving as controls, displayed impaired TLR3-, but not TNFR1-mediated, necroptotic and apoptotic signaling (fig. The gene discussed is UNC93B1; the disease is herpes simplex encephalitis.