Whereas the other cluster of macrophages existed in the combination group, classical M1 macrophages not only exhibited activation of the functions mentioned previously herein, in Figure 4K,L, but also showed stronger interactions with DCs, CD8+ T cells, and tumor cells in the combination group compared to those in the other groups (Figure 5G,H) through an analysis with CellphoneDB. Here, CD8A is linked to neoplasm.