IFNG and neoplasm: These results, combined with previous findings showing increased IFN‐γ secretion by T cells, are consistent with other studies that have reported that IFN‐γ can increase the expression of adhesion molecules, such as ICAM1, and decrease endothelial VEGFA expression, which in turn promotes the infiltration of immune cells.[27] In summary, low‐dose sorafenib, alone or in combination with R848, normalizes the tumor vasculature, which is associated with a probable positive feedback loop to establish an antitumor immune environment.