It has been reported that spermatogenesis in Nectin2 knockout mice deviates from the normal developmental process, resulting in an infertile phenotype.[38, 39] Decreased activity of the Notch1 and Jagged 2 system may lead to cell maturation arrest in human testes.[40] We also analyzed the interactions between ST and other cells, and the results revealed that there were dynamic changes in the iNOA state (Figure S5C–E, Supporting Information). Here, NOTCH1 is linked to Infertility.