NECTIN2 and Infertility: It has been reported that spermatogenesis in Nectin2 knockout mice deviates from the normal developmental process, resulting in an infertile phenotype.[38, 39] Decreased activity of the Notch1 and Jagged 2 system may lead to cell maturation arrest in human testes.[40] We also analyzed the interactions between ST and other cells, and the results revealed that there were dynamic changes in the iNOA state (Figure S5C–E, Supporting Information).