Given the strong implication of Yap1 in brain tumor initiation, we finally scored control and Yap1‐5SA‐expressing cells for their expression of glioblastoma stem cell‐related genes (glioblastoma stem cell‐like signature; Castellan et al, 2021), such as the Yap1 paralogue transcriptional regulator Taz and some of their primary downstream transcriptional regulators (Fig 4F). This evidence concerns the gene WWTR1 and brain neoplasm.