CBD and hemp extracts rich in CBD can also reduce the expression of ACE2 [25] and TMPRSS2 [26] (both of which are human cell surface receptors that facilitate infection by SAR-CoV-2), and block induction of inflammatory mediators cyclooxygenase-2, IL-6, and IL-8 via the protein kinase B (AKT) pathway [25,26] (Figure 2). Here, ACE2 is linked to infection.