ACE2 and COVID-19: By measuring mRNA changes in lung alveolar A549 cells that had been stably overexpressed with human ACE2 and infected by SARS-CoV-2 with or without CBD treatment (2.5 μM), Nguyen et al. [27] concluded that CBD can inhibit the stimulation of cytokines associated with COVID-19 and that a mechanism of action might include activation of serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1α.